Unraveling the Chemical Properties of Methylone: Implications for Pharmacology and Toxicology


Methylone, a synthetic cathinone derivative, has gained attention for its stimulant and empathogenic effects, as well as its potential for misuse and abuse. Examining its chemical properties is crucial for understanding its pharmacological actions and toxicological implications.

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Chemical Identity:

  • Chemical Name: Methylone
  • Molecular Formula: C11H13NO3
  • Chemical Structure:
  • Synonyms: βk-MDMA, 3,4-Methylenedioxy-N-methylcathinone

Physical Properties:

  • Appearance: Methylone typically presents as a white to off-white crystalline powder or crystalline solid.
  • Melting Point: The melting point of methylone falls within the range of approximately 150-155°C.
  • Boiling Point: Methylone decomposes upon heating, and a precise boiling point is challenging to determine.
  • Solubility: It is sparingly soluble in water but dissolves readily in organic solvents such as ethanol and acetone.

Chemical Properties:

  • Stability: Methylone is relatively stable under ambient conditions but may undergo degradation upon exposure to heat, light, or acidic or basic environments.
  • Reactivity: It undergoes various chemical transformations, including reduction, oxidation, and formation of amine derivatives.
  • Pharmacophore: Methylone contains a methylenedioxyphenyl ring and an aminoethyl side chain, imparting distinct pharmacological properties similar to other cathinone derivatives.

Pharmacological Effects:

  • Stimulant Activity: Methylone acts as a central nervous system stimulant, increasing alertness, energy levels, and sociability.
  • Empathogenic Effects: Users may experience enhanced mood, empathy, and emotional openness upon consuming methylone.
  • Risk of Adverse Effects: Methylone use is associated with potential adverse effects such as anxiety, agitation, and cardiovascular complications.

Toxicological Considerations:

  • Acute Toxicity: High doses of methylone can lead to acute toxicity, manifested by symptoms such as hypertension, hyperthermia, and serotonin syndrome.
  • Chronic Effects: Chronic use of methylone may result in tolerance, dependence, and psychiatric disturbances, highlighting the importance of risk mitigation strategies.


Methylone exhibits complex chemical and pharmacological properties, contributing to its stimulant and empathogenic effects. However, its potential for adverse effects and abuse underscores the need for further research into its pharmacology, toxicology, and regulatory control to mitigate public health risks associated with its use.

Information for preparing this article was taken from the site: https://en.wikipedia.org/wiki/Methylone

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